Dear all I recently came across the "experimental design" method for systematic optimization of multiparametric problems like macromolecular crystal growth. (The response surface concept has been introduced to protein crystallization by Carter et al. (e.g. Meth. Mol. Biol, vol. 363) and should theoretically enable optimization of a multiparatmetric problem by simultaneous variation of several variables).
I am wondering if anyone is actually making use of this method on a regular basis and what their experiences are. It would also be interesting to now if tools (web-based) are available to help in designing and evaluating experiments. Any comment appreciated! Thanks very much Christian
