Yes - reading early articles is always illuminating. Over the past few years I have looked at Charles Galton Darwin's (yes a relation) 1914 paper and Arthur Compton's in order to understand what is really happens to these x-rays. However, as Bayes work is being highlighted, I can't resist giving some of my favourite references to supplement the excellent ones already mentioned. They are given in order - of increasing complexity/length.
What is Bayesian Statistics - Sean Eddy, Nature Biotechnology 22, 1177 (2004). It seems to be available on ftp://selab.janelia.org/pub/publications/Eddy-ATG3/Eddy-ATG3-reprint.pdf <ftp://selab.janelia.org/pub/publications/Eddy-ATG3/Eddy-ATG3-reprint.pd f> Thomas Loredo's "Return of the Prodigal", available at http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.55.3616 <http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.55.3616> . Written for Astronomers but the principles apply to crystallography. A more philosophical treatment can be found in Ed Jayne's posthumously published opus magnum Probability Theory:The Logic Of Science - E.T. Jaynes. (Incomplete version at http://www-biba.inrialpes.fr/Jaynes/prob.html <http://www-biba.inrialpes.fr/Jaynes/prob.html> ). I think it is excellently written but not everyone likes his style. Happy reading Colin ________________________________ From: CCP4 bulletin board [mailto:[EMAIL PROTECTED] On Behalf Of Jacob Keller Sent: 22 September 2008 18:31 To: CCP4BB@JISCMAIL.AC.UK Subject: Re: [ccp4bb] Crystallogrphy today Since this is not so big and several people asked for it, I just sent it to the list. I hope no offence is taken... JPK ******************************************* Jacob Pearson Keller Northwestern University Medical Scientist Training Program Dallos Laboratory F. Searle 1-240 2240 Campus Drive Evanston IL 60208 lab: 847.491.2438 cel: 773.608.9185 email: [EMAIL PROTECTED] ******************************************* ----- Original Message ----- From: Jacob Keller <mailto:[EMAIL PROTECTED]> To: CCP4BB@JISCMAIL.AC.UK Sent: Monday, September 22, 2008 12:21 PM Subject: Re: [ccp4bb] Crystallogrphy today How about: "LII. An Essay towards solving a Problem in the Doctrine of Chances. By the late Rev. Mr. Bayes, communicated by Mr. Price, in a letter to John Canton, M. A. and F. R. S." I have the .pdf if anybody wants it... JPK ******************************************* Jacob Pearson Keller Northwestern University Medical Scientist Training Program Dallos Laboratory F. Searle 1-240 2240 Campus Drive Evanston IL 60208 lab: 847.491.2438 cel: 773.608.9185 email: [EMAIL PROTECTED] ******************************************* ----- Original Message ----- From: amit sharma <mailto:[EMAIL PROTECTED]> To: CCP4BB@JISCMAIL.AC.UK Sent: Monday, September 22, 2008 11:36 AM Subject: Re: [ccp4bb] Crystallogrphy today Hi Jayashankar, I think it is indeed very important to understand the very basics and origins of the key concepts in crystallography. To that effect, I found the paper 'Liking likelihood' by Airlie J. McCoy extremely useful, as I always wanted to understand this concept clearly. Also, the Proceedings of the CCP4 study weekends (Acta D) have been of great help in me understanding some key concepts. It is indeed quite exciting to be able to understand the concepts that seem to be difficult initially. Cheers, Amit Sharma, Department of Biology, University of York, United Kingdom. On 22/09/2008, Jayashankar <[EMAIL PROTECTED]> wrote: Dear Jacob, You are absolutely right, I was very much excited and clear when I read Randy J.Read 's paper Improved Fourier coefficients for maps using phases from partial structures with errors. its a must read paper for all students like me. thanks S.Jayashankar Research Student Institute for Biophysical Chemistry Hannover Medical School Germany. On Mon, Sep 22, 2008 at 5:52 PM, Jacob Keller <[EMAIL PROTECTED]> wrote: To understand the fundamentals of any discipline, I have always found it completely worthwhile to go back to the original source, where the idea was first discovered or presented. This is really, really valuable, although not always possible. I wonder whether others agree with me about this...but I feel pretty strongly about this matter. Often one can read many reviews on some subject, which never really get to the gist of the matter, but when one reads the original source, the subject is usually laid out clearly because guess what: nobody knew it yet, so it had to be explained clearly. Furthermore, one gets a sense of the excitement of discovery, and the unsurety about some new proposed hypothesis which has not yet become cannonized into fact. For this reason, it is sometimes even worthwhile to saunter down to the...library! Jacob Keller ******************************************* Jacob Pearson Keller Northwestern University Medical Scientist Training Program Dallos Laboratory F. 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