Closing date: 4 July 2008
A Research Associate position in protein crystallography is available
within the group of Prof. Paul Freemont (Division of Molecular
Biosciences, Imperial College London: www.imperial.ac.uk/molecularbiosciences)
as part of the Imperial College Small Molecule Cancer Drug Discovery
Programme funded by CRUK and is available immediately for a period of
3 years, with a possibility of renewal for a further 2 years (subject
to funding). The aim of the programme is to create a pipeline for
small molecule anti-cancer drug discovery and development, using a
chemistry-biology interface with protein crystallography to optimise
lead compounds. The overall goal of the programme is to develop and
test novel anti-cancer compounds in humans as led by clinicians in
the Imperial College Cancer group at Hammersmith Hospital led by Prof.
Charles Coombes. The small molecule programme is highly focused and
will require the appointed research associate to work on a variety of
protein targets in collaboration with clinical scientists as part of
an interdisciplinary team that encompasses a major part of the drug
discovery pipeline, including synthetic and medicinal chemistry, chemo-
informatics, rational drug design, molecular and cell biology and
clinical biochemistry.
The successful candidate will have a PhD or equivalent qualification
in a relevant research area and previous research experience in
structural biology using primarily protein crystallography. The
project will also require research experience and skills in
recombinant protein expression, purification, crystallisation and
small-ligand screening using protein crystallography and other
biophysical methods.
Further details and an application form can be obtained from the
College employment website: http://www3.imperial.ac.uk/employment/research
.
Completed application forms accompanied by a curriculum vitae and the
names and contact details of two referees should be sent to: Mrs Naomi
Anderson-Eyles, Imperial College London, Room 503, Biochemistry
Building, Exhibition Road, London, SW7 2AZ or by email to: [EMAIL PROTECTED]
