To the CCP4 community, I have a sequence that I would like to model by threading onto each subunit of a homo-tetramer of a related protein (crystal structure). It doesn't work to thread each subunit individually and then 'recombine' the homodimer as a single PDB because the interfaces suffer from clashes and overlaps. Does anyone know of a server that can peform multimer threading based on a sequence and a multimeric crystal structure?
Thank you for the advice, Best Regards, -Andy Torelli