Dear Miriam
I had that case of the 4-helix bundle FAT domain of Focal Adhesion
Kinase. It crystallised as a helix-swapped dimer (PDB ID 1k04,
1mol/ASU), as a non-swapped 4helix bundle (1ow7, 3 mol/ASU), and as a
hybrid, where 2 mols / ASU were not swapped, and one was swapped (1ow6).
With best wishes
Stefan
Miriam-Rose Ash a écrit :
Hey all,
Sorry for the off-topic post, but I'm just wondering if anyone has heard of any
examples in which a single crystal contained both the domain-swapped and
unswapped forms of a protein?
Thanks!
Miriam
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Stefan T. Arold, PhD
Centre de Biochimie Structurale
CNRS UMR 5048 - UM 1 - INSERM UMR 554
29 rue de Navacelles 34090
MONTPELLIER Cedex - France
email: [EMAIL PROTECTED]
Phone: +33 (0)4.67.41.77.02
Fax: +33 (0)4.67.41.79.13
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