Good day,

> I have DNA data. Is there any other solution rather than Rsubread which is 
> extremely slow?

How much of it do you have? If it's a large size, such as whole genome 
sequencing, then it would take longer than an RNA-seq experiment regardless of 
the algorithm you use. I have used Rsubread in the past and I think it performs 
as well as the other popular alignment programs.

> I am making an algorithm where one of its steps should be to map the DNA 
> reads to the reference genome.

Although it's possible to do short read mapping with packages like Rbowtie, I 
don't think this preprocessing stage should happen in R which is a statistical 
programming language. Modularity is good.

--------------------------------------
Dario Strbenac
University of Sydney
Camperdown NSW 2050
Australia
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