tileGenome would generate the ranges if you wanted to regular bins over some part of the genome. Not sure what you use case is. But generating the ranges is probably the easy part.
On Mon, Nov 18, 2013 at 5:08 PM, Kasper Daniel Hansen < kasperdanielhan...@gmail.com> wrote: > tileGenome? > > Michael, making us do a prototype in R is a very reasonable request. We > should do that. > > Best, > Kasper > > > On Mon, Nov 18, 2013 at 7:45 PM, Tim Triche, Jr. <tim.tri...@gmail.com>wrote: > >> Doesn't tileGenome or whatever it's called help with the binning? It's >> not too hard to bolt multiple tracks into a SummarizedExperiment at that >> point. >> >> --t >> >> > On Nov 18, 2013, at 4:33 PM, Kasper Daniel Hansen < >> kasperdanielhan...@gmail.com> wrote: >> > >> > (Michael Love and I had some discussion on this Friday) >> > >> > I also think it would be a very convenient class/method. A lot of data >> > these days are naturally represented (and are available from say GEO) as >> > bigWig files (essentially coverage tracks), for example ChIP-seq. This >> > would be much more efficient than converting BAM to coverage on the fly. >> > >> > It seems to me that bigWig ought to be efficient for this, but I am not >> > very familiar with its performance. What we want is really to be able >> to >> > chunk multiple coverage profiles over the genome, and do computations on >> > each of the chunks. Any idea on efficiency? I am happy to contribute a >> > bit, at least with design. >> > >> > Best, >> > Kasper >> > >> > >> > On Mon, Nov 18, 2013 at 6:11 PM, Michael Lawrence < >> lawrence.mich...@gene.com >> >> wrote: >> > >> >> Aggregating coverage over multiple samples is a popular request >> recently. >> >> I'm happy to support this effort, but I thinks someone in Seattle is >> going >> >> to have to take the lead on it. >> >> >> >> >> >> On Mon, Nov 18, 2013 at 2:36 PM, Michael Love >> >> <michaelisaiahl...@gmail.com>wrote: >> >> >> >>> a discussion came up on devel last year about looking at a genomic >> range >> >>> over multiple samples and multiple experiments ( >> >> >> https://stat.ethz.ch/pipermail/bioc-devel/attachments/20120920/93a4fb61/attachment.pl >> >>> ) >> >>> >> >>> stepping aside the multiple experiment part, I'm interested in >> >>> BigWigViews() with fixed ranges across samples. Has there been any >> more >> >>> thoughts in this direction? >> >>> >> >>> BigWigViews would be incredibly useful for genomics applications >> where we >> >>> want to scan along the genome looking at lots of samples. BigWig >> offers a >> >>> concise representation of the information compared to BAM files. >> >>> >> >>> What I am trying now is using import(BigWigFile, which=gr) on files >> one >> >> by >> >>> one, and then binding the coverage together. >> >>> >> >>> best, >> >>> >> >>> Mike >> >>> >> >>> [[alternative HTML version deleted]] >> >>> >> >>> _______________________________________________ >> >>> Bioc-devel@r-project.org mailing list >> >>> https://stat.ethz.ch/mailman/listinfo/bioc-devel >> >> >> >> [[alternative HTML version deleted]] >> >> >> >> _______________________________________________ >> >> Bioc-devel@r-project.org mailing list >> >> https://stat.ethz.ch/mailman/listinfo/bioc-devel >> > >> > [[alternative HTML version deleted]] >> > >> > _______________________________________________ >> > Bioc-devel@r-project.org mailing list >> > https://stat.ethz.ch/mailman/listinfo/bioc-devel >> > > [[alternative HTML version deleted]] _______________________________________________ Bioc-devel@r-project.org mailing list https://stat.ethz.ch/mailman/listinfo/bioc-devel
