Partial interpolation over pattern sustitution

[J. Alejandro Ceballos Z.]

How may I avoid partial interpolation over a pattern sustitution?
My code looks like:
    # searching for all matches for later use
    @matches = $htmlpage =~ m/<pre>(.*?)<\/pre>/gs;
    for ($i=0; $i<$#matches; $i++)
      { $htmlpage =~ s/<pre>$matches[$i]<\/pre>/<predefined:$i\/>/; }
The problem comes when the matches contains regex characters, and they try 
to be evaluated (ex. '|+--..' must be interpeted like '\|\+--\.\.').

Is the only solution implement a pre-transform regex characters?
Any better (and fine) solution?
TIA,
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