The Nginx web server has it's own way to configure routing. Have a look at: http://nginx.org/en/docs/http/server_names.html
You might be able to get what you want simply by setting a default_application in routes.py: 1. in "web2py" directory, open "router.example.py" 2. modify "default_application = 'welcome'," to "default_application = 'myapp'," 3. save as "routes.py" 4. restart web2py