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*United States Patent Application* *20090010962 * *Kind Code* *A1 * *Palese;
Peter ; et al.* *January 8, 2009 *
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Genetically Engineered Swine Influenza Virus and Uses Thereof
*Abstract*
The present invention relates, in general, to attenuated swine influenza
viruses having an impaired ability to antagonize the cellular interferon
(IFN) response, and the use of such attenuated viruses in vaccine and
pharmaceutical formulations. In particular, the invention relates to
attenuated swine influenza viruses having modifications to a swine NS1 gene
that diminish or eliminate the ability of the NS1 gene product to antagonize
the cellular IFN response. These viruses replicate in vivo, but demonstrate
decreased replication, virulence and increased attenuation, and therefore
are well suited for use in live virus vaccines, and pharmaceutical
formulations.
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Inventors: *Palese; Peter*; *(Leonia, NJ)* *; Garcia-Sastre; Adolfo*; *(New
York, NY)* *; Webby; Richard J.*; *(Memphis, TN)* *; Richt; Juergen
A.*; *(Ames,
IA)* *; Webster; Robert G.*; *(Memphis, TN)* *; Lager; Kelly M.*; *(Colo,
IA)* Correspondence Name and Address: *
JONES DAY
222 EAST 41ST ST
NEW YORK
NY
10017
US
* Assignee Name and Adress: *MOUNT SINAI SCHOOL OF MEDICINE OF NEW YORK
UNIVERSITY*
*New York*
*NY*
*ST. JUDE CHILDREN'S RESEARCH HOSPITAL*
*Memphis*
*TN*
*THE UNITED STATED OF AMERICA AS REPRESENTED BY THE SECRETARY OF AGRICULTURE
*
*Washington*
*DC*
Serial No.: *628292* Series Code: *11 * Filed: *June 1, 2005* PCT Filed: *June
1, 2005* PCT NO: *PCT/US2005/019382* 371 Date: *February 6, 2008*
