I've successfully been able to get two VMs setup with GPU/USB pass-through
and individually they both work, but I can't run both of them at the same
time.  Virt-manager will complain that the other's PCI device (GPU) is
already in use even though they don't share the same GPU.

I suspect it is because both GPUs have the same IOMMU group that is being
assigned to the vfio driver.  I was hoping there would be some way to make
this work as they are both being controlled by vfio.

Here is my IOMMU grouping and I've attached my libvirt xmls

$ find /sys/kernel/iommu_groups/ -type l
/sys/kernel/iommu_groups/17/devices/0000:07:00.0
/sys/kernel/iommu_groups/17/devices/0000:06:01.0
/sys/kernel/iommu_groups/7/devices/0000:00:1c.1
/sys/kernel/iommu_groups/15/devices/0000:04:00.0
/sys/kernel/iommu_groups/5/devices/0000:00:17.0
/sys/kernel/iommu_groups/23/devices/0000:0d:00.0
/sys/kernel/iommu_groups/13/devices/0000:00:1f.6
/sys/kernel/iommu_groups/3/devices/0000:00:14.2
/sys/kernel/iommu_groups/3/devices/0000:00:14.0
/sys/kernel/iommu_groups/21/devices/0000:06:07.0
/sys/kernel/iommu_groups/21/devices/0000:0b:00.0
/sys/kernel/iommu_groups/11/devices/0000:00:1d.4
*/sys/kernel/iommu_groups/1/devices/0000:02:00.1*
*/sys/kernel/iommu_groups/1/devices/0000:01:00.1*
*/sys/kernel/iommu_groups/1/devices/0000:00:01.2*
*/sys/kernel/iommu_groups/1/devices/0000:00:01.0*
*/sys/kernel/iommu_groups/1/devices/0000:02:00.0*
*/sys/kernel/iommu_groups/1/devices/0000:01:00.0*
/sys/kernel/iommu_groups/18/devices/0000:06:04.0
/sys/kernel/iommu_groups/8/devices/0000:00:1c.2
/sys/kernel/iommu_groups/16/devices/0000:05:00.0
/sys/kernel/iommu_groups/6/devices/0000:00:1c.0
/sys/kernel/iommu_groups/24/devices/0000:0e:00.0
/sys/kernel/iommu_groups/14/devices/0000:03:00.0
/sys/kernel/iommu_groups/4/devices/0000:00:16.0
/sys/kernel/iommu_groups/22/devices/0000:0c:00.0
/sys/kernel/iommu_groups/12/devices/0000:00:1f.3
/sys/kernel/iommu_groups/12/devices/0000:00:1f.4
/sys/kernel/iommu_groups/12/devices/0000:00:1f.2
/sys/kernel/iommu_groups/12/devices/0000:00:1f.0
/sys/kernel/iommu_groups/2/devices/0000:00:02.0
/sys/kernel/iommu_groups/20/devices/0000:0a:00.0
/sys/kernel/iommu_groups/20/devices/0000:06:06.0
/sys/kernel/iommu_groups/10/devices/0000:00:1d.0
/sys/kernel/iommu_groups/0/devices/0000:00:00.0
/sys/kernel/iommu_groups/19/devices/0000:06:05.0
/sys/kernel/iommu_groups/19/devices/0000:09:00.0
/sys/kernel/iommu_groups/9/devices/0000:00:1c.4
<domain type='kvm'>
  <name>win10</name>
  <uuid>1d55aee4-49f4-4948-9e4f-f2cceb69237b</uuid>
  <memory unit='KiB'>16384000</memory>
  <currentMemory unit='KiB'>16384000</currentMemory>
  <vcpu placement='static'>4</vcpu>
  <cputune>
    <vcpupin vcpu='0' cpuset='4'/>
    <vcpupin vcpu='1' cpuset='5'/>
    <vcpupin vcpu='2' cpuset='6'/>
    <vcpupin vcpu='3' cpuset='7'/>
  </cputune>
  <os>
    <type arch='x86_64' machine='pc-i440fx-2.6'>hvm</type>
    <loader readonly='yes' type='pflash'>/usr/share/edk2/ovmf/OVMF_CODE.fd</loader>
    <nvram>/var/lib/libvirt/qemu/nvram/win10_VARS.fd</nvram>
    <bootmenu enable='no'/>
  </os>
  <features>
    <acpi/>
    <apic/>
    <hyperv>
      <relaxed state='on'/>
      <vapic state='on'/>
      <spinlocks state='on' retries='8191'/>
      <vendor_id state='on' value='whatever'/>
    </hyperv>
    <kvm>
      <hidden state='on'/>
    </kvm>
    <vmport state='off'/>
  </features>
  <cpu mode='host-passthrough'>
    <topology sockets='1' cores='4' threads='1'/>
  </cpu>
  <clock offset='localtime'>
    <timer name='hypervclock' present='yes'/>
    <timer name='rtc' tickpolicy='catchup'/>
    <timer name='pit' tickpolicy='delay'/>
    <timer name='hpet' present='no'/>
  </clock>
  <on_poweroff>destroy</on_poweroff>
  <on_reboot>restart</on_reboot>
  <on_crash>restart</on_crash>
  <pm>
    <suspend-to-mem enabled='no'/>
    <suspend-to-disk enabled='no'/>
  </pm>
  <devices>
    <emulator>/usr/bin/qemu-kvm</emulator>
    <disk type='file' device='disk'>
      <driver name='qemu' type='qcow2'/>
      <source file='/var/lib/libvirt/images/win10.qcow2'/>
      <target dev='vdc' bus='virtio'/>
      <boot order='1'/>
      <address type='pci' domain='0x0000' bus='0x00' slot='0x0b' function='0x0'/>
    </disk>
    <disk type='block' device='disk'>
      <driver name='qemu' type='raw' cache='none' io='native'/>
      <source dev='/dev/disk/by-path/ip-10.10.10.0:3260-iscsi-iqn.2011-03.org.dsreed.istgt:windows10vm-lun-0'/>
      <target dev='vdd' bus='virtio'/>
      <address type='pci' domain='0x0000' bus='0x00' slot='0x0a' function='0x0'/>
    </disk>
    <disk type='file' device='cdrom'>
      <driver name='qemu' type='raw'/>
      <source file='/var/lib/libvirt/images/isos/virtio-win.iso'/>
      <target dev='hdb' bus='ide'/>
      <readonly/>
      <address type='drive' controller='0' bus='0' target='0' unit='1'/>
    </disk>
    <controller type='usb' index='0' model='ich9-ehci1'>
      <address type='pci' domain='0x0000' bus='0x00' slot='0x05' function='0x7'/>
    </controller>
    <controller type='usb' index='0' model='ich9-uhci1'>
      <master startport='0'/>
      <address type='pci' domain='0x0000' bus='0x00' slot='0x05' function='0x0' multifunction='on'/>
    </controller>
    <controller type='usb' index='0' model='ich9-uhci2'>
      <master startport='2'/>
      <address type='pci' domain='0x0000' bus='0x00' slot='0x05' function='0x1'/>
    </controller>
    <controller type='usb' index='0' model='ich9-uhci3'>
      <master startport='4'/>
      <address type='pci' domain='0x0000' bus='0x00' slot='0x05' function='0x2'/>
    </controller>
    <controller type='pci' index='0' model='pci-root'/>
    <controller type='ide' index='0'>
      <address type='pci' domain='0x0000' bus='0x00' slot='0x01' function='0x1'/>
    </controller>
    <controller type='virtio-serial' index='0'>
      <address type='pci' domain='0x0000' bus='0x00' slot='0x07' function='0x0'/>
    </controller>
    <interface type='bridge'>
      <mac address='52:54:00:77:e8:57'/>
      <source bridge='br0'/>
      <model type='virtio'/>
      <address type='pci' domain='0x0000' bus='0x00' slot='0x02' function='0x0'/>
    </interface>
    <input type='mouse' bus='ps2'/>
    <input type='keyboard' bus='ps2'/>
    <sound model='ich6'>
      <address type='pci' domain='0x0000' bus='0x00' slot='0x03' function='0x0'/>
    </sound>
    <hostdev mode='subsystem' type='pci' managed='yes'>
      <source>
        <address domain='0x0000' bus='0x01' slot='0x00' function='0x0'/>
      </source>
      <address type='pci' domain='0x0000' bus='0x00' slot='0x04' function='0x0'/>
    </hostdev>
    <hostdev mode='subsystem' type='pci' managed='yes'>
      <source>
        <address domain='0x0000' bus='0x01' slot='0x00' function='0x1'/>
      </source>
      <address type='pci' domain='0x0000' bus='0x00' slot='0x06' function='0x0'/>
    </hostdev>
    <hostdev mode='subsystem' type='pci' managed='yes'>
      <source>
        <address domain='0x0000' bus='0x0b' slot='0x00' function='0x0'/>
      </source>
      <address type='pci' domain='0x0000' bus='0x00' slot='0x08' function='0x0'/>
    </hostdev>
    <memballoon model='virtio'>
      <address type='pci' domain='0x0000' bus='0x00' slot='0x09' function='0x0'/>
    </memballoon>
  </devices>
</domain>

<domain type='kvm' id='7'>
  <name>steph-win10</name>
  <uuid>6b396360-81be-4f29-9a04-90c3ea03e174</uuid>
  <memory unit='KiB'>4194304</memory>
  <currentMemory unit='KiB'>4194304</currentMemory>
  <vcpu placement='static'>2</vcpu>
  <resource>
    <partition>/machine</partition>
  </resource>
  <os>
    <type arch='x86_64' machine='pc-i440fx-2.6'>hvm</type>
    <loader readonly='yes' type='pflash'>/usr/share/edk2.git/ovmf-x64/OVMF_CODE-pure-efi.fd</loader>
    <nvram>/var/lib/libvirt/qemu/nvram/steph-win10_VARS.fd</nvram>
    <boot dev='hd'/>
  </os>
  <features>
    <acpi/>
    <apic/>
    <hyperv>
      <relaxed state='on'/>
      <vapic state='on'/>
      <spinlocks state='on' retries='8191'/>
      <vendor_id state='on' value='whatever'/>
    </hyperv>
    <kvm>
      <hidden state='on'/>
    </kvm>
    <vmport state='off'/>
  </features>
  <cpu mode='host-model'>
    <model fallback='allow'/>
  </cpu>
  <clock offset='localtime'>
    <timer name='rtc' tickpolicy='catchup'/>
    <timer name='pit' tickpolicy='delay'/>
    <timer name='hpet' present='no'/>
    <timer name='hypervclock' present='yes'/>
  </clock>
  <on_poweroff>destroy</on_poweroff>
  <on_reboot>restart</on_reboot>
  <on_crash>restart</on_crash>
  <pm>
    <suspend-to-mem enabled='no'/>
    <suspend-to-disk enabled='no'/>
  </pm>
  <devices>
    <emulator>/usr/bin/qemu-kvm</emulator>
    <disk type='block' device='disk'>
      <driver name='qemu' type='raw' cache='none' io='native'/>
      <source dev='/dev/disk/by-path/ip-10.10.10.0:3260-iscsi-iqn.2011-03.org.dsreed.istgt:windows10vm-lun-1'/>
      <backingStore/>
      <target dev='hda' bus='ide'/>
      <alias name='ide0-0-0'/>
      <address type='drive' controller='0' bus='0' target='0' unit='0'/>
    </disk>
    <disk type='file' device='cdrom'>
      <driver name='qemu' type='raw'/>
      <source file='/var/lib/libvirt/images/isos/virtio-win.iso'/>
      <backingStore/>
      <target dev='hdb' bus='ide'/>
      <readonly/>
      <alias name='ide0-0-1'/>
      <address type='drive' controller='0' bus='0' target='0' unit='1'/>
    </disk>
    <controller type='usb' index='0' model='ich9-ehci1'>
      <alias name='usb'/>
      <address type='pci' domain='0x0000' bus='0x00' slot='0x06' function='0x7'/>
    </controller>
    <controller type='usb' index='0' model='ich9-uhci1'>
      <alias name='usb'/>
      <master startport='0'/>
      <address type='pci' domain='0x0000' bus='0x00' slot='0x06' function='0x0' multifunction='on'/>
    </controller>
    <controller type='usb' index='0' model='ich9-uhci2'>
      <alias name='usb'/>
      <master startport='2'/>
      <address type='pci' domain='0x0000' bus='0x00' slot='0x06' function='0x1'/>
    </controller>
    <controller type='usb' index='0' model='ich9-uhci3'>
      <alias name='usb'/>
      <master startport='4'/>
      <address type='pci' domain='0x0000' bus='0x00' slot='0x06' function='0x2'/>
    </controller>
    <controller type='pci' index='0' model='pci-root'>
      <alias name='pci.0'/>
    </controller>
    <controller type='ide' index='0'>
      <alias name='ide'/>
      <address type='pci' domain='0x0000' bus='0x00' slot='0x01' function='0x1'/>
    </controller>
    <interface type='bridge'>
      <mac address='52:54:00:76:c7:c7'/>
      <source bridge='br0'/>
      <target dev='vnet0'/>
      <model type='rtl8139'/>
      <alias name='net0'/>
      <address type='pci' domain='0x0000' bus='0x00' slot='0x03' function='0x0'/>
    </interface>
    <input type='mouse' bus='ps2'>
      <alias name='input0'/>
    </input>
    <input type='keyboard' bus='ps2'>
      <alias name='input1'/>
    </input>
    <hostdev mode='subsystem' type='pci' managed='yes'>
      <driver name='vfio'/>
      <source>
        <address domain='0x0000' bus='0x03' slot='0x00' function='0x0'/>
      </source>
      <alias name='hostdev0'/>
      <address type='pci' domain='0x0000' bus='0x00' slot='0x07' function='0x0'/>
    </hostdev>
    <hostdev mode='subsystem' type='pci' managed='yes'>
      <driver name='vfio'/>
      <source>
        <address domain='0x0000' bus='0x02' slot='0x00' function='0x0'/>
      </source>
      <alias name='hostdev1'/>
      <address type='pci' domain='0x0000' bus='0x00' slot='0x09' function='0x0'/>
    </hostdev>
    <hostdev mode='subsystem' type='pci' managed='yes'>
      <driver name='vfio'/>
      <source>
        <address domain='0x0000' bus='0x02' slot='0x00' function='0x1'/>
      </source>
      <alias name='hostdev2'/>
      <address type='pci' domain='0x0000' bus='0x00' slot='0x0a' function='0x0'/>
    </hostdev>
    <memballoon model='virtio'>
      <alias name='balloon0'/>
      <address type='pci' domain='0x0000' bus='0x00' slot='0x08' function='0x0'/>
    </memballoon>
  </devices>
  <seclabel type='none' model='none'/>
  <seclabel type='dynamic' model='dac' relabel='yes'>
    <label>+107:+986</label>
    <imagelabel>+107:+986</imagelabel>
  </seclabel>
</domain>

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