Thanks guys, for all the helpful info and sanity checks! :) Sorry about the Message-ID munging - I get some really useful malware at that domain but no ham, and am a bit paranoid about losing that feed.
Followup: >I had considered anchoring the MIME string, however we have a >very powerful quarantine system, so I kept that rule simple. >We've had zero FPs on either rule, albeit only in xml/doc/msword >files. I changed my system to run that MIME string test on all message parts (plain text, de-MIMEd file, de-MIMEd non-file MIME), then we did a regression test on all 2015 & 2016 ham for most of our key corpora. We also tested 2013 & 2014 ham-only for a few of the most useful corpora, for a grand total of about 1.4 million individual emails. We found exactly zero hits on ham. :) Not counting "my" SA list digest. That rule is now live on all our systems, at Exterminate score. We'll be doing a few more corpora in the next two weeks, and if there's any hits, I'll report back. While it is hypothetically possible that somebody would send a document with ActiveMime, I personally am trusting my quarantine sytem to detect those. We can individually "skip" list that rule if needed, just like we already do with Word macros and other Pakled-icity. ;) - "Chip"