I'm running in to this same problem - I've been trying to debug this all
morning.

The error message is ambiguous and appears to be directly connected to
spamassassin.  I upgraded to 3.3.1 and rebuilt, and the problem happens
still.   It seems to happen for large sites like aol.com, facebook.com, ...
there are others that work fine, such as Google Gmail.

I do not have any grey-listing installed.  These messages are being rejected
with an ambiguous:

Milter: data, reject=451 4.3.2 Please try again later

and it doesn't make any sense.   I've checked the socket file, permissions,
etc.  I don't see any errors in the logs. 

What could be causing this?  It's becoming a problem as mails are not being
received inbound.


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