Rob,

> Been running Spamassassin for a long time with no problems until a
> recent update of various packages including perl (but no other
> immediately perceptible relevant update) and now this error:
> 
> Oct 30 15:34:31 <hostname deleted>  spamd[16264]: dns: sendto()
> failed: Connection refused at /usr/lib/perl5/vendor_perl/5.8.8/Mail/
> SpamAssassin/DnsResolver.pm line 395
> 
> CentOS 5.4-4, SpamAssassin 3.2.5  running as:
> /usr/bin/spamd -d -c -m9 -H -r /var/run/spamd.pid
> Perl just updated to perl-5.8.8-27.el5.i386

man 2 send

[ECONNREFUSED]
  The socket received an ICMP destination unreachable
  message from the last message sent.  This typically
  means that the receiver is not listening on the remote port.


Check health of the first DNS resolver as specified in your /etc/resolv.conf.
Is it alive? Is a firewall or OS policy blocking queries?

  Mark

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