At 11:14 PM 7/14/2009, you wrote:

No doubt this has been discussed before and apologies for any repetition, but
I can't find the answer in the archive.

I have set SA to reject all mail that isn't addressed to specific addresses,

No, SpamAssassin isn't rejecting the mail, something else is.

but quite a lot of spam gets through by using arbitrary addresses in the To
field and a 'good' address in the Envelope-to field.

How can I rectify this?

Why is your MTA not verifying addresses, and rejecting mail to non valid addresses?

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