>   do you know if there is a way to have a blacklist, either for user or
> eventually for an entire server, that could be feeded via some scripts ?

Yes create your own dns blacklist

> A sort of auto_learn but only for addresses ( to or from ) ?

No such thing as only for... You have to implement multiple things and try to 
catch the default crap at an early stage by something that does not consume 
much resources.
I have have my from= and/or to= dnsbl at the end of all checks

Currently I am marking spam at server level and individual users can white list 
messages marked as spam. So next time when a marked message arrives, it is 
unmarked again.
But this is not done via dnsbl but with a local user whitelist db with sieve. 


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