If you block something, you have to ask yourself: How many innocent,
unsuspecting legitimate senders
Who cares, these "unsuspecting legitimate senders" should take their
business somewhere else.
This is extremist. You are confusing offenders with victims. Fight offenders, not victims. Every single rule in the default SpamAssassin ruleset is targeted against offenders, not against victims. I propose you keep it that way. If you start to block everything that once sent spam, you end up blocking half of the internet. You have to accept this is an ongoing war against spammers, and every time you add a new rule to detect spam content, the spammers adapt and invent new ways to circumvent. You cannot go further than dnsbl with their automated and temporary blocks - if you start to block manually mail providers as some answer suggested, this is usually a permanent block and from then on a permanent nuisance for own customers who expect mail from outlook.com users and a permanent nuisance for remote customers who chose outlook.com as provider. A nuisance that is more severe than some undetected spam mail. You forgot: spam detection by content still works. Outlook.com is not on some whitelist.

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