Insulin resistance [b][url=http://diabetesdestroyersystemreview.com/]Diabetes Destroyer[/url][/b] often leads to Beta-Cell destruction through various mechanism listed below. However, some individuals may have limited Beta-Cellmass early in life because of genetic factors predisposing them to diabetes.
Central Obesity is the main risk factor for the development of diabetes. It is often accompanied by an elevation of lipids in the blood (dyslipidemia) and increased circulating leptin and cytokine levels. All of these factors have been shown to modulate Beta-cell function and survival. The influence of dyslipidemia on the Beta-cells of an individual will depend on his or her specific lipid profile. Whereas some free fatty acids and lipoproteins have been shown to be pro-apoptotic for the Beta-cell, others are protective. Thus, long-term exposure to saturated fatty acids such as palmitate (a saturated fatty acid that is found in humans, animals and plants and is a major component of palm oil) appears highly toxic, whereas monounsaturated fatty acids such as oleate protect against both palmitate- and glucose-induced Beta-Cellapoptosis. It is interesting to note that similar toxic effects are also observed in non-Beta-cells such as cardiac cells. Lipoproteins may affect Beta-Cellsurvival in a similar way, whereby VLDL and LDL are pro-apoptotic and HDL is protective. [b][url=http://diabetesdestroyersystemviews.com/]http://diabetesdestroyersystemviews.com/[/url][/b] Mitochondrial dysfunction has also been proposed as a common feature of both impaired insulin responsiveness of peripheral tissues and defective Beta-Cellsecretory function and survival. -- Context is everything: http://forum.magnolia-cms.com/forum/thread.html?threadId=4acac53c-7839-436c-9bc1-9df4c8437a5c ---------------------------------------------------------------- For list details, see http://www.magnolia-cms.com/community/mailing-lists.html Alternatively, use our forums: http://forum.magnolia-cms.com/ To unsubscribe, E-mail to: <user-list-unsubscr...@magnolia-cms.com> ----------------------------------------------------------------
