I've got a similar problem with 7.10 on a Toshiba Tecra A9. If I suspend or 
hibernate the ttyS0 no longer works.
Doing stty < /dev/ttyS0 says std input: Input/output error. Setserial 
/dev/ttyS0 still sees it. Using setserial to (re)set the irq, port etc doesn't 
seem to do much.

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Serial port stops working after suspend
https://bugs.launchpad.net/bugs/105380
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