Have the same behaviour on my Lenovo Thinkpad T460s (20FAS0FD07) running 
5.15.0-33-generic:
1. laptop can't get out of suspend
2. boot is longer than with 21.10 due to the time out of TPM 

[    0.027286] ACPI: Reserving TPM2 table memory at [mem 0xcfff8000-0xcfff8033]
[    5.122778] tpm tpm0: Operation Timed out
[   11.946910] tpm tpm0: Operation Timed out
[   11.946942] tpm_crb: probe of MSFT0101:00 failed with error -62
[   12.023475] ima: No TPM chip found, activating TPM-bypass!

(^^ extract of "demsg | grep -i tpm")

Thanks,
Nicolas

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https://bugs.launchpad.net/bugs/1971567

Title:
  TPM breaks resume from suspend

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