Just adding a note that this can also happen in Gnome on a system without XFCE.
Commenting out: x-scheme-handler/file=exo-file-manager.desktop In the file: ~/.local/share/applications/mimeapps.list Like the Fedora note above worked. Not sure if a new ticket is needed to address the but outside of Xubuntu. Ubuntu 18.04, happened after upgrade from 16.04 -- You received this bug notification because you are a member of Ubuntu Bugs, which is subscribed to Ubuntu. https://bugs.launchpad.net/bugs/1778069 Title: [xfce] nautilus don't open files if set as default file manager To manage notifications about this bug go to: https://bugs.launchpad.net/exo/+bug/1778069/+subscriptions -- ubuntu-bugs mailing list ubuntu-bugs@lists.ubuntu.com https://lists.ubuntu.com/mailman/listinfo/ubuntu-bugs