I think the main hint is in comment #15:

  tessa@viper:~$ pacmd list
  Daemon not responding.

This means pulseaudio has either hung, crashed or been killed. Please
follow these instructions to see if you can find any evidence of a
crash:

https://wiki.ubuntu.com/Bugs/Responses#Missing_a_crash_report_or_having_a_.crash_attachment

If not, and if the pulseaudio daemon is still running and not responding
to 'pacmd list' then please try forcing a crash report with:

  killall -ABRT pulseaudio

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https://bugs.launchpad.net/bugs/1799007

Title:
  [System76 Oryx Pro] no sound after 18.10 upgrade

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