@kaihengfeng I can confirm that commenting out that line does indeed solve the problem.
$ cat /etc/default/grub GRUB_DEFAULT=saved GRUB_SAVEDEFAULT=true GRUB_HIDDEN_TIMEOUT_QUIET=true GRUB_TIMEOUT=10 GRUB_DISTRIBUTOR=`lsb_release -i -s 2> /dev/null || echo Debian` GRUB_CMDLINE_LINUX_DEFAULT="quiet splash" GRUB_CMDLINE_LINUX="" $ cat /etc/modprobe.d/blacklist.conf (...) # causes failure to suspend on HP compaq nc6000 (Ubuntu: #10306) # blacklist i2c_i801 <-- COMMENTED OUT (...) Which means that, whatever does the module 'i2c_i801' to cause suspend failures on the HP Compaq NC6000, it also in direct or indirect charge of making the two-finger scrolling work on the Lenovo Thinkpad series T400. My system: Lenovo Thinkpad T450s Linux Mint 18.3 (based on Ubuntu 16.04 Xenial) $ uname -a Linux ThinkPad 4.13.0-39-generic #44~16.04.1-Ubuntu SMP Thu Apr 5 16:43:10 UTC 2018 x86_64 x86_64 x86_64 GNU/Linux -- You received this bug notification because you are a member of Ubuntu Bugs, which is subscribed to Ubuntu. https://bugs.launchpad.net/bugs/1722478 Title: Two-finger scrolling no longer works after resuming from suspend To manage notifications about this bug go to: https://bugs.launchpad.net/linux/+bug/1722478/+subscriptions -- ubuntu-bugs mailing list ubuntu-bugs@lists.ubuntu.com https://lists.ubuntu.com/mailman/listinfo/ubuntu-bugs