@kaihengfeng I can confirm that commenting out that line does indeed
solve the problem.

$ cat /etc/default/grub
GRUB_DEFAULT=saved
GRUB_SAVEDEFAULT=true
GRUB_HIDDEN_TIMEOUT_QUIET=true
GRUB_TIMEOUT=10
GRUB_DISTRIBUTOR=`lsb_release -i -s 2> /dev/null || echo Debian`
GRUB_CMDLINE_LINUX_DEFAULT="quiet splash"
GRUB_CMDLINE_LINUX=""

$ cat /etc/modprobe.d/blacklist.conf
(...)
# causes failure to suspend on HP compaq nc6000 (Ubuntu: #10306)
# blacklist i2c_i801  <-- COMMENTED OUT
(...)

Which means that, whatever does the module 'i2c_i801' to cause suspend
failures on the HP Compaq NC6000, it also in direct or indirect charge
of making the two-finger scrolling work on the Lenovo Thinkpad series
T400.

My system:
Lenovo Thinkpad T450s
Linux Mint 18.3 (based on Ubuntu 16.04 Xenial)
$ uname -a
Linux ThinkPad 4.13.0-39-generic #44~16.04.1-Ubuntu SMP Thu Apr 5 16:43:10 UTC 
2018 x86_64 x86_64 x86_64 GNU/Linux

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https://bugs.launchpad.net/bugs/1722478

Title:
  Two-finger scrolling no longer works after resuming from suspend

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