Another verified work-around that needs no alteration to the PATH:
1. sudo apt-get purge python-pip python3-pip
2. Delete all of the pip/pip3 stuff under .local including the packages.
3. sudo apt-get install python-pip python3-pip
4. Using pip and/or pip3, reinstall needed Python packages.

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https://bugs.launchpad.net/bugs/1772746

Title:
  After upgrade to 18.04, all pip and pip3 commands fail

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