Upgrading to 18.04 seems has made this bug appear for me. I have tried updating to the latest kernel but that did not help.
$ uname -a Linux erikkallen-laptop 4.17.0-041700rc4-generic #201805070430 SMP Mon May 7 04:31:46 UTC 2018 x86_64 x86_64 x86_64 GNU/Linux $ lsb_release -a No LSB modules are available. Distributor ID: Ubuntu Description: Ubuntu 18.04 LTS Release: 18.04 Codename: bionic -- You received this bug notification because you are a member of Ubuntu Bugs, which is subscribed to Ubuntu. https://bugs.launchpad.net/bugs/1413440 Title: USB stops working after a while (xhci_hcd 0000:00:14.0: Timeout while waiting for setup device command) To manage notifications about this bug go to: https://bugs.launchpad.net/system76/+bug/1413440/+subscriptions -- ubuntu-bugs mailing list ubuntu-bugs@lists.ubuntu.com https://lists.ubuntu.com/mailman/listinfo/ubuntu-bugs