It seems that I have the same issue here:

Host:   windows 7 x64 VirtualBox 5.2.8 
Guest:  lubuntu 16.04 amd64
virtualbox-guest-dkms-hwe installed from standard repos (and associated 
utils-hwe and x11-hwe).

After upgrading guest additions(the above three packages only) from
5.0.40 to 5.1.34 and guest reboot Firefox and some other apps do not
start in the guest.

When an affected app is run  via a mouse click nothing happens except
the mouse pointer changes to hour glass for about ten seconds. When the
mouse pointer is in that state I do not see the launched app in the
output of `ps` utility.

When run from bash console the affected apps produce no output, just
exit.

Apps that do not start:
  firefox, synaptic, galculator

Apps that are ok:
  pcmanfm, leafpad, all qt-based programs

** Attachment added: "apt and dkms  log"
   
https://bugs.launchpad.net/ubuntu/+source/virtualbox/+bug/1758946/+attachment/5092433/+files/vb.dkms.log

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https://bugs.launchpad.net/bugs/1758946

Title:
  virtualbox-guest-utils update caused Synaptic to stop working

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