Just a small precision about Jorge's last comment above
(<https://bugs.launchpad.net/ubuntu/+source/python2.7/+bug/1638695/comments/10>):

"I cleaned out all the resulting callgrind files removing the files
smaller than 100k and the ones that were not loading the cPickle
extension (https://pastebin.canonical.com/175951/)."

That URL is not publicly accessible, here are the commands Jorge ran:

find . -type f -size -100k -exec rm {} \;
for f in $(ack-grep -i pickle | grep callgrind.out | cut -d":" -f1 | uniq); do 
mv $f $f.pick; done
for f in $(ls *.pick); do callgrind_annotate $f > $f.annotate; done

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https://bugs.launchpad.net/bugs/1638695

Title:
  Python 2.7.12 performance regression

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