Thank you Joseph, the upstream kernel from months ago was the cause of the issue. I had completely forgotten about it being there and did not recognise the change in version numbering as significant.
I followed the steps outlined in http://askubuntu.com/a/594484/109072 to remove the kernel and a reboot now comepletes cleanly. The steps I performed were: > If compiled and installed via make install, you will need to manually remove > the following entries: > > /boot/vmlinuz*KERNEL-VERSION* > /boot/initrd*KERNEL-VERSION* > /boot/System-map*KERNEL-VERSION* > /boot/config-*KERNEL-VERSION* > /lib/modules/*KERNEL-VERSION*/ > /var/lib/initramfs/*KERNEL-VERSION*/ Where KERNEL-VERSION for me was 4.4.21*. -- You received this bug notification because you are a member of Ubuntu Bugs, which is subscribed to Ubuntu. https://bugs.launchpad.net/bugs/1653636 Title: Kernel panic - not syncing: VFS: Unable to mount root fs on unknown- block(0,0) To manage notifications about this bug go to: https://bugs.launchpad.net/ubuntu/+source/linux/+bug/1653636/+subscriptions -- ubuntu-bugs mailing list ubuntu-bugs@lists.ubuntu.com https://lists.ubuntu.com/mailman/listinfo/ubuntu-bugs