I had this problem, this solved it:

/etc/default/grub

GRUB_CMDLINE_LINUX="i8042.nomux=1 i8042.reset"

credit and complete instructions:

 http://forums.linuxmint.com/viewtopi...uchpad#p813402

My system:
LENOVO ThinkPad Twist 33476LU
carl@twist:~$ sudo dmidecode -s bios-release-date
07/01/2013
carl@twist:~$ sudo dmidecode -s bios-version
GDET97WW (1.57 )

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https://bugs.launchpad.net/bugs/1210748

Title:
  On Lenovo Thinkpad Twist internal mouse does not work after turning on
  machine, only works after reboot

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