I had this problem, this solved it: /etc/default/grub
GRUB_CMDLINE_LINUX="i8042.nomux=1 i8042.reset" credit and complete instructions: http://forums.linuxmint.com/viewtopi...uchpad#p813402 My system: LENOVO ThinkPad Twist 33476LU carl@twist:~$ sudo dmidecode -s bios-release-date 07/01/2013 carl@twist:~$ sudo dmidecode -s bios-version GDET97WW (1.57 ) -- You received this bug notification because you are a member of Ubuntu Bugs, which is subscribed to Ubuntu. https://bugs.launchpad.net/bugs/1210748 Title: On Lenovo Thinkpad Twist internal mouse does not work after turning on machine, only works after reboot To manage notifications about this bug go to: https://bugs.launchpad.net/ubuntu/+source/linux/+bug/1210748/+subscriptions -- ubuntu-bugs mailing list ubuntu-bugs@lists.ubuntu.com https://lists.ubuntu.com/mailman/listinfo/ubuntu-bugs