I had the same issue, turns out the bug involved is pretty old and has to do with alsa & pulseaudio: http://askubuntu.com/questions/118675 /mute-key-mutes-alsa-and-pulseaudio-but-unmutes-only-alsa
Quick and diry solution: sed -i 's/amixer/amixer -D pulse/' ~/.config/openbox/lubuntu-rc.xml When I fixed this, I discovered a concurrency bug in amixer; if you keep the VolUp/Down button pressed, the new amixer command will get executed before the old one has finished, leading to unbalanced volume in my case. I fixed this by executing ~/volup.sh, ~/voldown.sh and ~/volmute.sh instead of the amixer commands in lbuntu-rc.xml, and having the following scripts in my homedir: ~$ tail vol*sh ==> voldown.sh <== #!/bin/bash [ ! -e ~/amixerlock ] && touch ~/amixerlock && amixer -D pulse -q sset Master 3%- && rm ~/amixerlock ==> volmute.sh <== #!/bin/bash [ ! -e ~/amixerlock ] && touch ~/amixerlock && amixer -D pulse -q sset Master toggle && rm ~/amixerlock ==> volup.sh <== #!/bin/bash [ ! -e ~/amixerlock ] && touch ~/amixerlock && amixer -D pulse -q sset Master 3%+ && rm ~/amixerlock -- You received this bug notification because you are a member of Ubuntu Bugs, which is subscribed to Ubuntu. https://bugs.launchpad.net/bugs/1262572 Title: lxpanel volume control cannot be toggled mute/unmute with keyboard To manage notifications about this bug go to: https://bugs.launchpad.net/ubuntu/+source/lxpanel/+bug/1262572/+subscriptions -- ubuntu-bugs mailing list ubuntu-bugs@lists.ubuntu.com https://lists.ubuntu.com/mailman/listinfo/ubuntu-bugs