Same problem here

I just added
"/usr/share/roundcube:/usr/share/php:/var/lib/roundcube:/etc/roundcube"
to open_basedir configuration and roundcube works !

Don't forget restart APACHE

Make sure, you don't have open_basedir reconfigured in <location /> tags
somwere in apache2 configuration, like i had. In that case php.ini
setting has no effect.

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https://bugs.launchpad.net/bugs/759974

Title:
  PHP Fatal error:  Class 'PEAR' not found in
  /usr/share/roundcube/program/include/iniset.php on line 132

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