I did some googling. <http://www.loci.wisc.edu/visbio/data.html> has a couple of zip files with bio-rad samples. Like I sort of suspected, typical values for image size are more like 512 x 512 and maybe a dozen images tops in a file; the numbers reported by file(1) above are way outside the typical range and would, I believe, require absolutely huge files. So maybe some simple sanity checks could be put in instead, or as well.
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