I believe I have the same problem. I think it is related to issues with the ath9k driver and network manager, because at first I had it happen after a few minutes of being logged in. Using wicd instead I had no lockups, but as long as Ubuntu One requires NetworkManager, I need to use it. After some troubleshooting and doing some research I decided to install the new ath9k driver, which is in the backports modules package. This made the lockups much less frequent, but they still happen. I have just reinstalled wicd to see if it really is due to ath9k/NetworkManager.
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