I think this is a dup of bug #75461. When you logout then quickly login again, deskbar gets some stale environment variables and any programs launched by it are affected. One of those variables is the D-BUS socket path. When epiphany can't connect to D-BUS it can't make sure it is the only instance running, and so disables the profile to avoid corruption.
-- Launching epiphany from deskbar doesn't use the user profile https://launchpad.net/bugs/72557 -- ubuntu-bugs mailing list ubuntu-bugs@lists.ubuntu.com https://lists.ubuntu.com/mailman/listinfo/ubuntu-bugs
