I have the same issue on Toshiba Satellite L20-182 (basically, it's the same as 
L20-183, it just has got less RAM and smaller HDD, AFAIK). I can't shutdown my 
laptop normally, lsusb doesn't work, re-pluging the mouse (Logitech BT 58 OEM 
optical mouse) doesn't help (the computer doesn't even provide power for the 
mouse, it's red light is off), my pendrive doesn't work either.
However, graphics acceleration seem to work flawlessly.

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[FGLRX] kernel drivers kills USB subsystem
https://launchpad.net/bugs/41272

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