++++Position-1++++

Title: Postdoc or Staff Scientist in Bioinformatics


Location: University of Arizona, Tucson, Arizona, USA


Position Summary:


 The Center for Innovation in Brain Science (CIBS) is the intellectual home for

Neuroscience research across the University of Arizona campus. We specialize in

research focusing on a cure for four neurodegenerative diseases; Alzheimer’s

Disease, Amyotrophic Lateral Sclerosis (ALS), Multiple Sclerosis, and 
Parkinson’s

Disease. Our mission is to bring the innovations in brain science of the future 
to

those who need a cure today.


Dr. Chang’s lab in CIBS is an interdisciplinary lab composed by computer 
scientists, bioinformaticians and biologists dedicated to researches from 
developing advanced mathematic algorithms in statistics/machine learning to 
applied real-world disease modeling. Our researches are fund by NIH. We work 
with a wide spectrum of disease conditions, including cancer, stem cell, 
Type2-Diabetics, Cardiovascular diseases, and neurodegenerative diseases 
(Alzheimer’s disease, MS, ALS, and

Parkinson Disease, Lewy Body Dimentia). We collaborate with clinicians, 
wet-labs at UofA as well as labs at world-class institutions, such as Columbia, 
Stanford, Duke, Mayo Clinic, Harvard/Broad, Emory, and Baylor, providing 
enormous opportunities for exciting research projects and high impact 
publications.


Our lab is seeking a motivated and high-quality scientist to join our team to 
work on computational systems biology and human diseases modeling. The 
expectation is that the selected candidate will focus on real-world disease 
modeling and have a strong background in biology and bioinformatics. The 
candidate will be responsible for processing and analyzing multi-scale omics 
data, such as WGS/WES, RNAseq data by applying cutting-edge NGS analysis 
methods.


The successful candidate will be supervised by Dr. Rui Chang and will have 
opportunity to develop their own research ideas as they fit within the general 
research interests of our group. The position will offer very competitive 
salary. The post is based at the University of Arizona, Tucson campus, within 
the Center for Innovation in Brain Science.



Minimum Qualifications

1)PhD degree in biology, bioinformatics, biostatistics, computational biology 
or a related field.


2)Demonstrated experience in writing scientific papers in analyzing omics data 
towards real-world disease modeling


3)Demonstrated working experiences in analyzing NGS data, including not limited 
to WGS, WES, RNA-seq data


4)Extensive experience in sequencing data tools such as Picard tools, SAMtools, 
FastQC, aligners such as BWA, Tophat, STAR, variant calling pipelines such as 
GATK tools / Queue, SAMtools mpileup, annotation packages and resources such as 
Ensembl, GENCODE, BLAST, GSEA, mSigDB, GWAS catalog, OMIM, KEGG, online data 
resources such as GTEx, TCGA, GEO, dbGaP, genotype processing, QC and analysis 
tools such as PLINK, IMPUTE2, relevant R packages such as limma, edgeR, 
MatrixEqtl, RNAseq tools such as featureCounts, HTSeq, Cufflinks.


5)Experience in pre-processing and imputation of single-cell RNA-seq data is a 
plus.


Duties & Responsibilities:

-Disease modeling

-Bioinformatics

-Processing and analyzing multi scale omics data.

-Applying cutting edge methods to reconstruct disease models.

-Generate in silico hypothesis on drug targets.

-Work with our interdisciplinary team and wet-lab collaborators.


Time & Benefits

-Full Time: 40 hour per week

-Salary: $50,000 - $60,000 Annually, DOE

-Outstanding UA benefits include health, dental, and vision insurance plans; 
life insurance and disability programs; paid vacation, sick leave, and 
holidays; UA/ASU/NAU tuition reduction for the employee and qualified family 
members; state and optional retirement plans; access to UA recreation and 
cultural activities; and more!


Apply:

Please send cover letter and CV to Dr. Rui Chang

ruich...@email.arizona.edu<mailto:ruich...@email.arizona.edu>





++++Position-2++++

Title: Postdoc or Staff Scientist Position in Computational Biology


Location: University of Arizona, Tucson, Arizona, USA


Position Summary:


The Center for Innovation in Brain Science (CIBS) is the intellectual home for 
Neuroscience research across the University of Arizona campus. We specialize in 
research focusing on a cure for four neurodegenerative diseases; Alzheimer’s 
Disease, Amyotrophic Lateral Sclerosis (ALS), Multiple Sclerosis, and 
Parkinson’s Disease. Our mission is to bring the innovations in brain science 
of the future to those who need a cure today.


Dr. Chang’s lab in CIBS is an interdisciplinary lab composed by computer 
scientists, bioinformaticians and biologists dedicated to researches from 
developing advanced mathematic algorithms in statistics/machine learning to 
applied real-world disease modeling. Our researches are fund by NIH. We work 
with a wide spectrum of disease conditions, including cancer, stem cell, 
Type2-Diabetics, Cardiovascular diseases, and neurodegenerative diseases 
(Alzheimer’s disease, MS, ALS, and

Parkinson Disease, Lewy Body Dimentia). We collaborate with clinicians, 
wet-labs at UofA as well as labs at world-class institutions, such as Columbia, 
Stanford, Duke, Mayo Clinic, Harvard/Broad, Emory, and Baylor, providing 
enormous opportunities for exciting research projects and high impact 
publications.


Our lab is seeking a motivated and high-quality Assistant Scientific 
Investigator to join our team to work on computational systems biology and 
human diseases modeling. The expectation is that this candidate will focus on 
real-world disease modeling and have a strong background in mathematics and 
statistics. The candidate will be responsible for processing and analyzing 
multi-scale omics data and applying cutting-edge machine learning and network 
modeling methods to reconstruct diseased models and generate in-silico 
hypothesis on drug targets.


The successful candidate will be supervised by Dr. Rui Chang and will develop 
cutting-edge computational systems biology approaches and apply advanced 
methods to integrate Big Data in real human disease and have exciting 
opportunity to interact with real biology wet-labs. The post is based at the 
University of Arizona, Tucson campus, within the Center for Innovation in Brain 
Science.


Minimum Qualifications

1)PhD degree in mathematics, statistics, computer science or physics.


2)Solid knowledge in statistics and machine learning. Strong working experience 
in Bayesian inference, and graphical models is highly preferred.


3)Strong, demonstrated programming skills in C/C++, Java, and R. Programming 
skills in additional languages is a plus.


Duties & Responsibilities:

-Disease modeling.

-Computational systems biology.

-Novel computational methods developments for integrating biological omics data.

-Software development.


Time & Benefits

-Full Time: 40 hr/week

-Salary: $60,000 - $70,00 Annually, DOE

-Outstanding UA benefits include health, dental, and vision insurance plans; 
life insurance and disability programs; paid vacation, sick leave, and 
holidays; UA/ASU/NAU tuition reduction for the employee and qualified family 
members; state and optional retirement plans; access to UA recreation and 
cultural activities; and more!


Apply:

Please send cover letter and CV to Dr. Rui Chang

ruich...@email.arizona.edu<mailto:ruich...@email.arizona.edu>


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