I'd design as much or all of the db-parts of the site to load over AJAX as
possible, so you can put up a nice "Loading..." message. Keep a persistent
connection to the database; don't connect for every client (pconnect in
PHP). Maybe do a redundant design that aims for eventual consistency if
you have to fallback to database B because you can't reach database A.
Have your site have very robust failure handling for timeouts, data not
read etc both client and server side.
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