Greetings,
Ran into an interesting software project that I thought I would share with this list:
http://dbmail.org/
This works with qmail to store all emails in a relational database (i.e. MySQL). I can see good points (faster mail access and easier load balancing in theory - although I guess this would depend some on what filesystem you use) and bad points (yet another piece of software to rely on for mail delivery/retrieval). With the clustering support coming up in MySQL 4.1 (http://dev.mysql.com/downloads/cluster/), this could certainly make mail server load balancing setups easier (no dependency on a central NFS server). They have an interesting schema for mail storage. I get the impression from their mailing list that some things like the IMAP server are a bit rough around the edges.
Anyways, thought it might be of some interest.
Mike