Hi Eric B.,
Thanks for your detailed and informative reply.
While drafting a recent Sursound post regarding KEMAR, I did a Google search to 
make sure I was spelling Zwislocki correctly. One reference that appeared at 
the top had something to do with inner ear simulation software--I need to go 
back and check it out. Anyway, I don't know whether the "front end" of 
available inner-ear simulation software allows the user to study neural coding 
with an arbitrary source or audio file. Analyzing complex sounds at the neural 
level (particularly innervation of inner hair cells) would require a lot of 
data-logging channels or replaying the stimulus over and over while 
systematically moving the 'logger' to the many virtual receptors. If such a 
simulation exists, one might be able to measure differences (at neural level) 
between a wav file and its mp3 counterpart. Considering that neural firing 
appears to be a lot more complicated than basilar membrane motion alone (which 
is primarily mechanical except for motile outer hair
 cell contributions to membrane elasticity), we might expect to use statistical 
measures to decide what significant differences, if any, exist. This still 
wouldn't provide conclusive evidence when it comes to perception. I realize 
there has been a long-standing debate over audio file types and rates, but my 
guess is that the subjects used in studies consisted of normal-hearing young 
people with no familial history of hearing loss. Normal hearing generally means 
thresholds = 10 dB HL or better at the audiometric test frequencies (highest 
test frequency being 8 kHz). Such screening measures are generally employed to 
ensure a 'normal' (and homogeneous) population. Perhaps people claiming to 
possess 'golden ears' have participated in mp3 vs wav studies, too. But this 
kind-of avoids the subtle issue of outliers or people who have (for example) 
auditory processing disorders or other abnormalities that are independent of 
hearing thresholds. We have a reasonable
 grasp on how mammals hear (the physiological aspect), but we don't know a 
whole lot about how we listen. Of course, just as with hybrid mixing, the way 
to avoid potential pitfalls or danger in a research or clinical environment is 
to avoid the lossy file types altogether.
Best,
Eric Carmichel (also not to be confused with Eric Carmichael--my last name has 
an unusual spelling. Cheers!)



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