There is a profiles.ini in %appdata%\mozilla\Seamonkey. If you delete the ini 
Seamonkey should start and create a new default profile. You can also edit it 
and 
see if the wrong profile is in it.

On Sun, 31 Jan 2016 12:33:30 -0500, Larry S. wrote:

>>When my wife set up SM in her new W10 computer, there was a bit of 
>>confusion about profiles. Eventually she got the one she wanted, and 
>>deleted the others (in Profile Manager). Now when she clicks on the SM 
>>logo it wants to open one of the profiles she deleted, resulting in File 
>>Not Found because that profile no longer exists.
>>
>>However, in Profile Manger she has indicated the correct one and clicked 
>>Use Profile. SM refuses to use this (correct) one and keeps opening with 
>>File Not Found.
>>
>>How do we fix this? All help gratefully appreciated!
>>
>>Larry


 Regards
 Frank-Rainer Grahl


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