Is such a thing possible with SpamAssassin and some other combinations in Redhat ??
Yes, this is largely a function of whatever tool you integrate SA with..
I'd suggest trying a mitler-level tool which can do this kind of thing by 550ing the message at delivery time. I think that qmail-scanner and spamasss-milter can both do it on this level, but I'm not greatly familiar with those tools.
I'd generally recommend avoiding the "post delivery DSN" type system that MailScanner uses.. Most of the spam will wind up bouncing again and land in your postmaster mailbox.
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