Is it possible? how ? IS there an another way ?
No, SA doesn't even reliably know who the recipient is, period. It doesn't see the message envelope, so it has to guess from the headers. It also doesn't support any direct kind of re-config.
However there are other ways.
One way I can think of is if you use spamd/spamc, you can have procmail figure out which domain the message is for. Create a non-login user account, complete with home directory and a user_prefs file, per domain. When you call spamc, use the -u parameter to cause it to run the config files for the "domain user" in question.
I also think that MailScanner can use some simple rules to decide which spamassassin user prefs file to run. I know it can do per-domain choices about most settings, so I can't see why not do the SA prefs file too.
amavisd-new, and other integrations may be able to do things like this as well.. but I have no experience with them.
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