Thanks to Martin and Henrik for an in-depth discussion that really helped me
quite a bit.
Requiring R-4.1.0 made it CRAN compliant and stopped the installation issues on
both check servers.
Considering the number of packages that use rtracklayer (it’s one of the most
used packages on Bioconduc
Is it possible this is a windows build issue? Based on the below, it seems
the InvalidUrlException only affects windows checks. These problems were
not present when radiant version 1.3.2 was submitted, else it wouldn't have
gotten on CRAN in the first place.
https://cran.r-project.org/web/checks/c