[R] Changing state in ODE

I am trying to fit data from human and animal pharmacokinetic studies in which drug concentrations have been determined over time over the course of several doses. In this case, the data are expected to be fit by a saturable (Michaelis-Menton) process. I can get the ode routine to run with on

[R] loess coefficients output

May I inquire about how to obtain the coefficients from a loess fit of multiple covariates? I have tried terms and coef, but it does not provide me with the coefficients to identify the terms of the entire regression equation. Many thanks Paul -- Paul R. Hutson, Pharm.D.