Welcome to path-based fingerprints. It is supposed to approximate
graph-edit distance, but here a single substitution leads to a large
change.
Anyhoo, just use -xs to see what each bit corresponds to and all
becomes clear (see the docs for more info):
C:\Users\noel>obabel -:Clc1c1 -:Fc1c1
Hello everybody,
recently I computed the Tanimoto between Clc1c1 and Fc1c1 with
openbabel by -ofpt and I was very surprised to see 0.3 as result.
Do you know if what I got is correct or what should I exactly do in
order to get the correct tanimoto between these two fragments?
Thank you t
