[NMusers] change from mass to molar units

boundary. Can anyone shed some light on why this happens? Is there any way to get around this? Could I keep the mass units and do some changes in the control stream when incorporating the metabolite data? Any help would be highly appreciated. Best regards Nele _ Nele

Antwort: Re: [NMusers] change from mass to molar units

heir molar mass and then multiplying with the molar mass of the parent. Would this be a reasonable approach, just to pretend that the metabolite is parent by using this calculation? Would the metabolite parameters still be correct then? Thanks for your help. Nele _____ N

[NMusers] change from mass to molar units

Dear all, there was a typo in the previous mail. The units were mg and µg/L or µmol and nmol/L. Any other suggestions what might happen? Nele _ Nele Plock Bayer Schering Pharma AG GPD/Pharmacokinetics Metabolism & Bioanalysis D- 13342 Berlin Phone : +49-30-468 15146

[NMusers] tumor growth model

INT ONEHEADER FILE=notab1 _____ Dr. Nele Plock Bayer Schering Pharma AG GPD/Pharmacokinetics Metabolism & Bioanalysis D- 13342 Berlin Phone : +49-30-468 15146 Fax: +49-30-468 95146 [EMAIL PROTECTED] http://www.bayerscheringpharma.de Vorstand: Arthur J. Higgins, Vorsitzender |

[NMusers] help with modelling of categorical response data

it is possible, how would I implement this? Thanks and best wishes Nele _ Dr. Nele Plock Bayer Schering Pharma AG Drug Metabolism & Pharmacokinetics Development Pharmacokinetics Scientific Expert Development Pharmacokinetics D- 13342 Berlin Phone : +49-30-468 15146 Fax:

[NMusers] PK/PD analyses in toxicology for tox prediction in humans

Dear all, in drug development, is anybody aware of examples of population PK/PD analyses in toxicology and how the resulting PKPD relation might be used for prediction of toxic effects in humans prior to first-in-man studies? Thanks and best regards Nele _ Dr. Nele

Antwort: [NMusers] PK/PD models to describe anti-ancer drug effect on the tumor volume

**2)*EPS(1) ; $DES CAV=A(5)/(T+0.01) RES=IC50*EXP(KRES*T*(1-CAV/(RED+CAV))) DADT(1)= -KA*A(1) DADT(2)= KA*A(1) -K20*A(2) DADT(3)= KEO*(PC*A(2)/V2 - A(3)) DADT(4)= KIN*(1-A(3)/(RES+A(3))) DADT(5)= A(3) _ Dr. Nele Plock Bayer Schering Pharma AG Drug Metabolism & Ph

Antwort: [NMusers] AUC Calculation in Simulation with and without EST

D=1 INTERACTION MAXEVAL=0 PRINT=5 NOABORT MSFO=msf001 $TABLE ID TIME CL V2 V3 Q KA F1 CC2 TOI1 TOI2 AOI1 AOI2 AUC1 AUC2 CMAX NOPRINT ONEHEADER FILE=notab1 _____ Dr. Nele Plock Bayer Schering Pharma AG Drug Metabolism & Pharmacokinetics Development Pharmacokinetics

[NMusers] Mechanistic modeling of estrous cycle

Dear all, has anybody ever mechanistically modeled ovulation in rats or any other species, taking LH, FSH or progesterone into account and would be willing to share some code? Thank you and best regards Nele _ Dr. Nele Plock Bayer Schering Pharma AG Drug Metabolism

Antwort: Re: [NMusers] enzyme auto inhibition PK model

Antiinfectives in the Treatment of Serious Grampositive Infections - Linezolid and Vancomycin (ISBN 978-3-86553-218-3, Wiku, Germany, 2007) Best regards Nele _ Dr. Nele Plock Bayer Schering Pharma AG Drug Metabolism & Pharmacokinetics Development Pharmacokine

[NMusers] cyst size modeling

TERVAL=24 ____ Dr. Nele Plock Bayer Schering Pharma AG Drug Metabolism & Pharmacokinetics Development Pharmacokinetics Scientific Expert Development Pharmacokinetics D- 13342 Berlin Phone : +49-30-468 15146 Fax: +49-30

[NMusers] higher AUC after bolus compared to infusion?

Dear all, I have trouble modeling some rat PK data obtained after intravenous dosing. I have dense data for two different doses, given either as bolus, half-hour or 3-hour infusion. We know that the compound has a large binding affinity to intracellular structures and therefore has a high volu

[NMusers] OMEGA BLOCK with mixture model?

there can't be a correlation. On the other hand, I did not include subpopulations for F1, so how can I keep this correlation to both CL-subgroups? Any thoughts on this would be highly appreciated! Best wishes Nele __ Dr. Nele P

RE: [NMusers] OMEGA BLOCK with mixture model?

can omit the correlation between the omegas. Also, thanks for all the tips how to correctly code the OMEGA BLOCK. Best regards Nele __ Dr. Nele Plock Pharmacometrics -- Modeling and Simulation Nycomed GmbH Byk-Gulden-Str. 2 D-78467

RE: [NMusers] OMEGA BLOCK with mixture model?

a one-compartment model, NONMEM would not be able to differentiate between IIV on volume or IIV on F1. But with more compartments, this should work, shouldn't it, even if I only have oral data? Best wishes Nele __ Dr.