[NMusers] incorporate lag time in ADVAN 6

Hi, I have concentration data from 4 clinical trials and one of those might have a lag time. A nonlinear model was used to fit the data. So I need to incorporate lag time into the differential equations. Does anybody know how to do this? Many thanks in advance. Best, Kehua

[NMusers] NONMEM VII and extracting the individual likelihoods

Dear NONMEM users, I did case deletion diagnostic on my model and foud that there might be some individuals deviate the population. Then I want to try extracting the individual likehoods to find out those individuals. Could anybody give me some guidence to do this? Many thanks in advance. Best

[NMusers] installation problem for NONMEM7 G95 on server

Dear NONMEM users, I am trying to install NONMEM 7 and G95 on a server. There is problem when testing the compiler, Pdx-pop says: >Testing GNU g95 Fortran >>>ld: cannot open output file C:\gmtest.exe: Permission denied Looks like I do not have the right. Can I avoid the 'C:\' disk? If so,

[NMusers] question about disease progress and drop out joint model

Dear NMusers, I am trying the joint modeling of disease progress and dropout model. NONMEM did not indicate any error, but it looks like did not run it and there is no results. I am following Chuanpu Hu and Mak E. Sale's method. Our disease progress model isy= base + (slope * time). Please fi

[NMusers] question about simulation based on joint disease progress and dropout model

Dear NMusers, We are trying to do VPC based on a joint disease progress and dropout model. But we did not get any results from the simulation. Does anybody have any suggestions? Thanks a lot. Kehua The control stream are below, $SUBS ADVAN6 TOL=6 $MODEL COMP=(CUMHAZ) COMP=(HZLAST) $PK

Re: [NMusers] question about simulation based on joint disease progress and dropout model

NDIF > ELSE ; after event so convert to missing > DVX=0 > DVIX=DVID > MDVX=1 > ENDIF >ENDIF > > > $TABLE ID TRT TIME DVX DVIX MDVX > NOAPPEND ONEHEADER NOPRINT FILE=joint.fit > > First subject in data.csv >#ID TR

[NMusers] repetitive parameter estimation

Hi, We have a data file with 250,000 simulated patients, and we want to estimate a parameter in NONMEM using a different set of 50 patients at a time (5,000 replicates, but not bootstrapping). Is there an easy way that anybody knows to automatically repeat the parameter estimation while substitut

[NMusers] protein binding model

Hi, I am trying to include the protein binding in my model and to estimate the unbound plasma concentration, using the total plasma concentration. The drug was taken orally. It seems that I can write the differential equations as below. A(2) and A(3) represent the unbound and bound amount, respec

[NMusers] question about incorporting genotyping data in disease progression model

Dear NONMEM users, I am working on a model in asthma patients and trying to build a model of FEV1, which is the evaluation of lung function. I have 500,000 genotyping data. First, I screened the genotyping data by running GWAS to find out the potential genotyping data, which gave me about 60 g

[NMusers] question in Box-Cox Transformations in K-PD model

Dear NONMEM users, I am trying to build a model to describe the drug toxicity on neuropathy. Since I am having dose and toxicity data, the K-PD model was applied in our model. The distribution of baseline is heavily left skewed. So I am also trying included the Box-cox transformation to get a accu

[NMusers] Fwd: question in Box-Cox Transformations in K-PD model

either.) $DES DADT(1)=-KDE*A(1) VIR=A(1)*KDE IRG=VIR COEF=1-(IRG*EMAX/(EDK50+IRG)) DADT(2)=KIN-KOUT*COEF*A(2) $ERROR IPRED=F IRES=DV-IPRED IF (F.EQ.0) FX=1 W=F+FX IWRES=IRES/W Y = F + ERR(1)+F*ERR(2) -- Forwarded message -- From: kehua wu Date: Mon, Aug 12, 2013