Dear All,
I am a hospital pharmacist and I am working on NONMEM as a new
user. I have modeled the oral immediate-released tacrolimus (Prograf) in
adult liver transplant patients.
Most of the data were trough concentration (about 1170 levels) from routine
monitoring tacrolimus data in
k instead of a
> trough). Perform the modeling and then try re-including the 'wrong'
> concentrations to show the impact to the model but I would still make the
> final model the one excluding those concentrations.
>
> Luann
>
> --
> *
88))*((HGB/10.50)**THETA(5))*((TB/4.7)**THETA(6))
> changes value every time that ALT, HGB, or TB changes value.
> The ETA(1) value remains the same for all observations within an
> individual but CL will still change with time because ALT, HGB, and TB
> change with time.
>
> How di
