Hi everyone,
I am developing a POP PK model for an anti-infective drug, I am trying to
determine if dosing should be weight based or not. The range of weight in the
study was 40-100 kg.
Weight was statistically significant for Cl/F but only explained 9% of the
variability observed for Cl.
is it to look at the variability explained by
a covariate? And can it be used to determine if a covrariate is not clinically
significant
Thanks,
Abdullah Sultan
From: Rudy Gunawan
Sent: Tuesday, December 8, 2015 8:10 PM
To: Sultan,Abdullah S; nmusers
Hi everyone,
I have a rich data set for a drug administered orally. The drug has slow
absorption (Tmax 4 hours) and rapid elimination (2 hours half life). A tlag
model was sufficient to describe the data but I ran into difficulties with the
error model.
If I use a proportional or combined er
From: Leonid Gibiansky
Sent: Tuesday, September 27, 2016 5:49:00 PM
To: Sultan,Abdullah S; nmusers@globomaxnm.com
Subject: Re: [NMusers] residual variability
Abdullah,
Do you have random effect on the lag time? Models with random effects on
the lag time are very difficult to work with, try to
