[NMusers] Negative eigenvalues, over-paramterization, finding most sensitive parameter

Hello Nick, Leonid, Dieter As a beginner in NONMEM society, I am becoming very curious in your current discussion. In a related situation I may need some helpful comments and already excuse myself if this question has been answered many times before. THE SITUATION: We have tissue (let's say

[NMusers] Differences in Covariance analysis between FOCE vs. IMPMAP

Dear NONMEM user The discussion about negative Eigenvalues during IMPMAP covariance analysis made me add this method after my standard FOCE run: $OMEGA BLOCK(2) 0.3 ;LOGETA_K40 0.1 0.3 ;LOGETA_K43 $OMEGA BLOCK(2) 0.3 ;LOGETA

AW: [NMusers] Negative eigenvalues, over-paramterization, finding most sensitive parameter

Dear Leonid Thank you for this informative response. It'll definitely help me in finding my bearings. Cheers Andreas Von: Leonid Gibiansky [mailto:lgibian...@quantpharm.com] Gesendet: Dienstag, 7. September 2010 17:08 An: Steingötter Andreas Cc: nmusers; Rickmer Braren Be

[NMusers] Comparing OFV from MCMC Bayesian models

Dear Baysian modellers We have generated a nine compartment model from extremely rich imaging data using MCMC Baysian analysis (and also SAEM during burn-in). For model evaluation we skip single or multiple compartments and compare the numerical outcomes such as the conditional weighted residua

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